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Beyond serving as a reducing cofactor for antioxidant enzymes, GSH exerts direct antioxidant activity by scavenging reactive oxygen species (ROS) and RNS, including superoxide anions (O 2 ), H 2 O 2 , and hydroxyl radicals (OH) 3

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First, Hcy condenses with serine to form cystathionine in a reaction catalyzed by cystathionine synthase (CBS), which requires vitamin B 6

SM and KZ are funded by the South African Medical Research Council (SAMRC) through its Division of Research Capacity Development under the internship scholarship program from funding received from the South African National Treasury