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Develops in the flat cells in the upper or outer part of the epidermis

supported an inverse relationship between plasma TMAO levels and IBD risk, suggesting that TMAO may exert a protective, rather than pathogenic, role in the context of IBD (123)

Several bioactive compounds modulate cytochrome P450 enzymes, particularly CYP3A4, CYP2D6, and CYP2C9, which are essential for the metabolism of chemotherapeutic agents and endocrine therapies

Then, monocytes pass through the endothelial tissue and transform into macrophages