impaired glutathione synthesis b12 Glossitis and hyperpigmentation of hands due to Vitamin deficiency. ⬇️ B12 leads to ⬆️ melanin more frequently in people with darker skin. Skin hyperpigmentation was reversed with B12 replacement Vitamin B12 and Reproductive Health:
Description
Acta Neuropathol (2005) 109(1):93108

PMID 24504062
Additionally, it increased the abundance of SCFA-producing bacteria like Roseburia, Clostridium, and Lachnospiraceae (Zhao et al., 2021)
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The structure of 2-methylimidazolidin-4-one adducts has been confirmed by proton NMR (Gidley et al., 1981) and 13 C-NMR spectroscopy (San George & Hoberman, 1986)