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In the context of methyl donors, an increase in plasma homocysteine, and hence SAH as a methyltransferase inhibitor, was reported in AD brain samples and correlated with cognitive impairment [140]

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Nerve conduction studies were normal, but EMG revealed both neuromyotonic and myokymic discharges along with fibrillations and fasciculations in multiple tested muscles of the arms and legs, worse distally

We therefore used a modified procedure 50 based on the fast reaction of cystamine with Cys34

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