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The His-Phe-Arg-Trp tetrapeptide core (positions 69) is preserved intact and has been identified as the pharmacophore responsible for melanocortin receptor activation
Data with nonnormal distribution were expressed as median (interquartile range (IQR)) and analyzed by the MannWhitney U test
Furthermore, the results obtained in human AD brains provide a map of specific oxidized proteins, which could be useful as biomarkers for diagnostic and therapeutic purposes
