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Antiparasitic activity of coumarin-chalcone (3-cinnamoyl-2H-chromen-2-ones) hybrids
Despite breakthroughs in peptide ligation technologies for producing complex proteins, preparing large protein analogs remains a major challenge due to slow reaction kinetics and limited scalability 95,96
In addition to its direct antimycobacterial activity, BA promotes bacterial clearance during mycobacterial infection through the activation of the NRF2KEAP1 and HO-1 signaling pathways ( Figure 3 )
