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5.2 Effects of bupivacaine on mitochondria Bupivacaine inhibits lipid-based respiration in cardiac mitochondria, mainly by blocking acylcarnitine exchange, which reduces mitochondrial respiratory function
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In skeletal muscle, L-Carnitine supplementation has also been shown to inhibit caspases, involved in the apoptotic process, and decrease levels of Tumor Necrosis Factor (TNF-) [64]
Transient receptor potential (TRP) vanilloid 4 (TRPV4) is a member of the Ca 2+ -permeable TRP superfamily
