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Half-life extension positively correlated with antibody affinity (Supplementary Fig

Osteopontin and CD44, markers of the HFSC niche, were also increased

These changes included mucosal erosion, ulcerative lesions, deformation and distortion of colonic recesses, extensive infiltration of inflammatory cells (primarily lymphocytes and neutrophils) in the mucosa and submucosa, and depletion of goblet cells

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