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Dihydroorotate dehydrogenase (DHODH), located in the inner mitochondrial membrane, is responsible for catalyzing the fourth step of the pyrimidine nucleotide synthesis pathway, namely the oxidation of dihydroorotate acid to orotate acid (OA), while CoQ10 in the inner membrane receives electrons to be reduced to CoQH2 [101]
Acromegaly: pathogenesis, diagnosis, and management

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