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The difference between strong functional tissue and weak scar tissue often comes down to how collagen fibers organize during healing

Accordingly, a Ca 2+ imaging study of the human submucosal plexus showed that under physiological conditions, communication from mast cells to nerves was rarely observed when mast cells were activated by IgE receptor crosslinking, which induces the release of a cocktail of mediators including proteases, histamine, and cytokines [122, 123]