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Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na + -glucose cotransport

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Funding This work was financially supported by the National Natural Science Foundation of China (82100447, 81602327), the Fundamental Research Funds for the Central Universities (2242023K40035), and the Zhishan Scholars Programs of Southeast University (2242021R41070)

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Moreover, these variants suppressed phosphorylation of SHP2 and ERK to a significantly greater extent than STAT3, with the D23L/S117N variant in particular reducing both SHP2 and ERK signaling by approximately 90%, despite retaining approximately 50% STAT3 activation relative to treatment with WT leptin alone (Fig