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Elkins MR, Robinson M, Rose BR, et al

You have the systemic, full-body anabolic environment from the elevated GH and systemic IGF-1, and then you have the targeted, potent, localized growth signal from the administered IGF 1 LR3

(114) is particularly significant as it examines the combined effects of total saponins from Stauntonia chinensis supplementation and aerobic exercise in a mouse model of NAFLD induced by a HFD

This concern arises from the fact that studies of hGH have shown that long-term exogenous administration, while increasing lean body mass and decreasing adipose tissue, can also cause: increased insulin resistance, diabetes, acromegaly, cancer, hypertension (high blood pressure), and edema (swelling)

Where possible, experimenters were blinded to the conditions being tested