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The nephrotoxicity was blocked by the GGT inhibitor AT-125 ((l-S,5S)--amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) and by aminooxyacetate (AOA), indicating the involvement of GGT and a cysteine S -conjugate -lyase, respectively, in the nephrotoxicity of hexachlorobutadiene S -conjugates (Schrenk et al., 1988a