aod9604 dosing protocol December 4, 2024 Pharmacy Compounding Advisory Committee (PCAC) Meeting AOD-9604 Dosage and Cycling: Injection

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Combine resistance training and aerobic activitypreclinical data suggest synergy with exercise [10]

Best published PK (Awosemo et al., 2021, rats): ~38% oral bioavailability, ~6 to 7 hr oral half-life

To ensure the absorbance from oil red O staining was within the linear detection range of the plate reader, a calibration curve was established for oil red O staining in adipocytes using a previously described protocol.[23] 2.12

The above procedure was repeated with inhibitor concentrations spanning 0.3 60 M to determine the effective concentration (EC 50 ) required to inhibit 50% NNMT activity in cultured adipocytes