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More in detail, microenvironmental factors (e.g., food, microbiota, bile acids) would permeate in excess through a leaky IEB, allowing amplification of signaling from the lumen to deeper mucosal and muscle layers, including overstimulation of the mucosal immune system (197)

The WT mice had considerably less DNA adducts (molecules that are strongly bonded to DNA that can lead to DNA breaks and mutations) than the KO mice

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Evidence suggests these two antioxidants work synergistically, meaning they help "recycle" and support one another to provide more robust cellular protection and immune support than if taken alone

What this means for clinical research: Early clinical programs will enter Phase I faster and with different evidence packages, shifting risk assessment earlier and increasing the importance of translational and modeling capabilities at the clinical interface