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Table 1: Reactive oxygen species and their sources

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Additionally, an acute administration of oxaliplatin upregulates the phosphoinositide 3-kinases - mammalian target of rapamycin receptor (PI3K-mTOR) pathways and the resultant expression of cytokines, interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, whilst inhibiting PI3K signalling reduces mechanical and cold hypersensitivity and the levels of proinflammatory cytokines (Duan et al., 2018)

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