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However, it is unclear if this abundance of thiomethyl derivates is related to a specific susceptibility of this individual to generate NAPQI metabolites, to the pregnancy itself (as sex steroids could be involved in the regulation of CYP2E1 ( 25 )) or to an accumulation of these metabolites in urine over time due to repeated intakes

In cases of chronic malabsorption, replacement therapy is needed with variable doses (50500 mg/day according to serum concentration) (78)

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observed that better outcomes (mortality, infection/complication rate, functional outcome score) were associated with early refeeding, a combination of parenteral and enteral nutrition, and immune enhancing formulas supplemented with a combination of probiotics, glutamine, arginine, fats (saturated and poly unsaturated, omega-3 fatty acids), protein, vitamins and minerals [114,115,116,117]