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Indeed, others had shown some time ago that mucosally-applied 5-HT reduces the threshold for peristalsis in the small intestine of guinea-pigs, that is likely mediated by the 5-HT3 receptor located on the mucosal, but not serosal surface of the bowel 111

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(Study: Frias et al., 2021) Side Effects: Tirzepatide's unique mechanism of action may result in distinct side effects compared to traditional GLP-1 RAs, necessitating careful monitoring and consideration

A particularly relevant finding involves the peptides effects on the Achilles tendon in rats

The peptide-histone interaction might disrupt histone-DNA binding, potentially enhancing gene accessibility for transcription
