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In this study, significant positive correlations were observed between tryptophan, tyrosine, and xanthine abundances in the EWAT and the relative abundance of Parasutterella in the cecal microbiome (Supplementary Table S5, outliers removed)

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These cholesterol reductions brought levels comparable to those seen in lean, healthy control mice, suggesting comprehensive metabolic normalization

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S., Vogensen, F

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In proof-of-concept studies, NNMT inhibitors (NNMTis) have demonstrated promise as potential treatments for obesity and obesity-related metabolic comorbidities (e.g., T2D, fatty liver) 8,9,13

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