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Since the heart cannot produce carnitine [284], it relies on uptake from the circulation [285], which explains the cause of cardiomyopathy in patients with primary carnitine deficiency

HIF-1 has been reported to be highly expressed in RA synovium (81), identifying this transcription factor as a hallmark of synovial tissue inflammation

Microbiome Recently, there has been an increasing focus on studying age-specific changes in the intestinal microbiome and its role in regulating inflammation

While supplementation with Clostridium has shown therapeutic effects on vasculitis animal models, its efficacy in patients remains to be confirmed