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For example, research into the molecular mechanisms underlying the effects of specific genetic polymorphisms on collagen synthesis and degradation can inform the development of pharmacological agents or gene therapies to enhance ligament strength and repair

In addition to evaluating the risk of bias using the RoB 2 tool for RCTs and the ROBINS-I tool for non-randomized studies, we also assessed the overall quality of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework

Collier AC, Ganley NA, Tingle MD, Blumenstein M, Marvin KW, Paxton JW et al

10.1046/j.1360-0443.1999.9479612.x [DOI] [PubMed] [Google Scholar] Willets J., Kelly E

But, nighttime supplementation may be beneficial for a few, particularly those with an inability to consume it in the morning or through an evening supplement regimen