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Phase 2: Cell Line Development and Process Development (Years 2-4) Simultaneously with analytical work, the developers manufacturing team constructs the expression system, typically a CHO (Chinese hamster ovary) cell line for monoclonal antibodies, and iterates upstream and downstream process parameters to hit the analytical target profile

Mater Interfaces 15 (21), 2511025121

Chau Y-Y, Bandiera R, Serrels A, Martnez-Estrada OM, Qing W, Lee M, et al

The collagen fibril organization and fibroblast proliferation markers were documented as key parameters

In aged monkeys, while the density of perforated synapses in the dentate gyrus is preserved in old relative to young monkeys, a reduction in synaptic contacts per axonal bouton was associated with cognitive impairment (Haberman et al., 2011)
