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Description
There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49

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doi:10.1016/s0022-3476(88)80114-8
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Tirzepatide does not prevent this metabolic adaptation entirely, but the degree of slowdown may be less than with diet-only weight loss
