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T4 acts mainly as a prohormone, while T3 is the biologically active form that directly affects metabolism, including basal metabolic rate (BMR), lipid metabolism, thermogenesis and carbohydrate metabolism [3]

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101 Several studies indicate that nicotine exerts neuroprotective effects via activation of nAChRs

The physiological role of Treg cells is to maintain immune tolerance by suppressing effector T-cell activity and preventing inappropriate immune responses