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At the cellular level, CKD is remarkable by oxidative stress, abnormal autophagy, and mitochondrial dysfunction accompanied by significant alterations in cell signaling pathways such as HIF, TGF-, and p53 activation [21]

Variations on an inhibitory theme: phasic and tonic activation of GABA A receptors
2 Materials and methods The project was approved by the Animal Use Ethics Committee of the Animal Science Institute, with protocol number CEUA/IZ 268-18
Sanford D, Lo-Coco F, Sanz MA, Di Bona E, Coutre S, Altman JK, et al
