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This causes the release of cyt c into the cell cytoplasm, which then activates a caspase cascade, particularly caspase-3 and caspase-9, resulting in mitochondrial impairment and triggering apoptosis (Yao et al., 2021)

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FIGURE 2 This oxidative stress environment can activate immune signalling pathways promoting neuroinflammation through mitochondrial dysfunction and impaired mitophagy, as observed in recent studies on ASD brains (Pinto Payares et al., 2024)

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Their primary mechanism involves reducing circulating cholesterol, binding to LDL particles, and enhancing systemic antioxidant activity (Zhang et al., 2023)

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