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Future studies leveraging the genetic tractability of Drosophila could further dissect the molecular pathways influenced by such natural compounds, accelerating the discovery of novel AD therapeutics

Crowe FL, Key TJ, Allen NE, Appleby PN, Roddam A, Overvad H, Grnbaek H, Tjnneland A, Halkjaer J, Dossus L, Boeing H, Krger J, Trichopoulou A, Dilis V, Trichopoulos D, Boutron-Ruault MC, De Lauzon B, Clavel-Chapelon F, Palli D, Berrino F, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Vrieling A, van Gils CH, Peeters PH, Gram IT, Skeie G, Lund E: The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition

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However, the direct mediation of drug resistance occurs due to the inhibition of forkhead box (FOX) proteins, especially forkhead box class O 3a (FOXO3a) (130)