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For example, in a randomized, double-blind, placebo-controlled trial in 60 participants diagnosed with an acute MI, neither mortality nor echocardiographic measures of cardiac function differed between patients treated with intravenous L-carnitine (6 g/day) for seven days followed by oral L-carnitine (3 g/day) for three months and those given a placebo (49)

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Changes of flux in any one of these pathways will influence pyruvate concentration and thus directly affect lactate concentration as the two are maintained close to thermodynamic equilibrium

The breakdown of the fatty acid molecule by -oxidation into smaller two carbon molecules permit their entry into the Krebs cycle and subsequent production of ATP [7,12]