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Description
This is because there is a competitive need for glutathione (GSH) to be used: 1) to clear H 2 O 2 , a byproduct of oxidative stress [10] , and, 2) to enable the detoxification of formaldehyde [17]
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Importantly, pharmacological modulation of NRF2 has emerged as a promising therapeutic strategy
10.1038/nm.2819 Nat
However, many factors, including their low stability, short half-life, high immunogenicity, tissue targeting, cellular uptake, and endosomal escape, hamper the delivery and clinical application of NADs
