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[3] A common repletion strategy in profoundly deficient adults involves 100,000 IU intramuscularly every four weeks for two or three doses or a one-off 300,000 IU injection followed by oral maintenance

119 In addition, other signalling pathways, such as the noncanonical Wnt, JAK/STAT, and Hedgehog (Hh) pathways, exhibit signalling crosstalk with the Wnt/-catenin signalling pathway, jointly achieving the regulation of bone homeostasis

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"Low" means the connection is primarily theoretical based on known mechanisms

Smaller volumes (below 0.2mL) inject quickly with minimal sensation but require more precise measurement