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Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes (Caballero et al., 2007)

Di Bisceglie AM, Axiotis CA, Hoofnagle JH, Bacon BR

PMID 21178401