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[DOI] [PubMed] [Google Scholar] 378.Vogel W, Graziadei I, Umlauft F, Datz C, Hackl F, Allinger S, et al

found that TMAO can inhibit the RCT process and affect cholesterol metabolism ( ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis ( coprostanol (a bacterial metabolite of cholesterol) ( Figure 3 Potential Therapeutic Measures of TMAO for AS Reduced Production of TMAO to Protect the Heart TMAO is an intestinal microbiota-dependent metabolite, which is accumulated in the body by ingestion of large amounts of substances rich in phosphatidylcholine

All of the present subjects completed acute testing with GPLC and PL in order to provide a consistent subject test exposure for the present investigation

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