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In addition to GLS inhibitors, strategies targeting the conversion of glutamate into -ketoglutarate, such as GDH inhibitors and aminotransferase inhibitors, have also been evaluated in preclinical models of breast cancer and neuroblastoma [103-105]

Mass spectrometry-based metabolomics analysis and stable isotope tracing To measure oxPPP and non-oxPPP activity, proliferating chondrocytes were cultured for 24 h in glucose-free DMEM supplemented with 10% dialysed FBS and 5.5 mM [1,2]- 13 C 2 -glucose (Cambridge Isotope Laboratories)

Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]
Some facilities can only run co-oximetry on ABG, otherwise can use VBG

The various settings and patients Liz has encountered over the years have enabled her to become very skilled at finding the smallest and most fragile of vessels