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Atherosclerosis is a degenerative disease of elastic and large muscular arteries manifesting as atheromatous changes in the tunica intima and thickening of the vessel wall via accumulation of plasma lipids (especially cholesterol) and connective extracellular matrix (ECM) (collagen fibers and proteoglycans) as well as the migration of cells (smooth muscle cells, monocytes/macrophages), which is accompanied by proliferation, calcification, ulceration, hemorrhage, and thrombosis formation

19 Moreover, a recent study revealed that the gut microbiota-derived metabolites, such as secondary bile acids and p -cresol sulfate, were enriched in PD patients with RBD