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132 Another controlled trial that included 120 subjects with tinnitus and low cochlear blood flow related to Mnire disease found 150 mg of Pycnogenol per day for six months improved cochlear blood flow and reduced subjective measures of tinnitus compared with no treatment

These new discoveries, together with the in-depth preclinical characterization of NAD + modulators and ongoing developments in their translation in humans, will open further avenues of study of this essential cofactor and its clinical therapeutic potential