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Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11,86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression

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10.1097/OGX.0000000000000925 Richard K Williams, John Raimondo, David Cahn, Aldon Williams, Daniel Schell

Deficiency in solute carrier family 25 member 15 (SLC25A15) causes reprogramming of glutamine metabolism, promoting HCC development [34]
