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These side effects are typically short-lived and resolve as your body clears the toxins and begins to heal

Taher-Mofrad SMJ, Topraggaleh TR, Ziarati N, Bucak MN, Nouri M, Seifi S, et al

10.1097/SHK.0b013e31826ae951 Shock (Augusta, Ga.) 140 StockwellB

Reference Lee SG, Nguyen NH, Lee YI, Jung I, Kim IA, Jang H, Shin H, Lee JH

For prescription topical formulations used consistently, initial improvements in texture, hydration, and radiance typically appear at 2 to 4 weeks, meaningful visible changes to firmness and fine lines at 4 to 8 weeks, maximum early results at 8 to 12 weeks, and full cumulative benefit at 3 to 6 months of consistent daily use