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Second, young FoxO4-null mice show no reproductive system impairment [29], indicating that FOXO4 does not play an important role in normal Leydig cells
Aberrant HLA-B27, gut microbiota and biomechanical stress such as orthograde posture trigger inflammation in collaboration with natural killer (NK) cells and helper T (Th) 17 cells, resulting in inflammation of the spine joints and sacroiliac joints with their adjacent soft tissues, tendons and ligaments (6)
Hatfield, J
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