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In addition, the limit of volumes (25250 l) for nasal administration, influence of nasal pathologic conditions such as rhinitis and common cold on the absorption, and potential for nasal irritation by drug administration in the nasal cavity, are significant factors governing in the choice of the nasal route for drug application (

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Genes Cells 18 , 3241 (2013)

4) Deletion of GHS-R attenuates inflammation (decreasing M1 macrophages) and reduces adiposity in both white and brown adipose tissues under diet-induced obesity and aging