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Moreover, the R17 Cagri- E14 Cagri ionic lock was present in the bypass conformation but absent in the CT-like conformation in both CagriBB-bound structures, consistent with a higher energy requirement to form the CT-like conformation (Supplementary Fig

Limitations and future directions First, this study focused solely on male APP/PS1 mice, so sex-specific effects were not assessed

Among PUFAs, omega-3 fatty acids, particularly alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are considered essential nutrients, since mammals lack the enzymes to synthesize them de novo and must obtain them from dietary sources (1, 2)

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