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These DAMPs activate the innate immune system, particularly Kupffer cells (liver-resident macrophages) and recruited monocytes, which release proinflammatory cytokines like TNF-, IL-1, and IL-6

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doi:10.1152/japplphysiol.91004.2008, PMID: 18845776 Soejima Y, Ostrowski RP, Manaenko A, Fujii M, Tang J, Zhang JH (2012) Hyperbaric oxygen preconditioning attenuates hyperglycemia enhanced hemorrhagic transformation after transient MCAO in rats