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Other mechanisms for EtOH-induced hepatic GSH depletion may involve increased efflux of GSH from the liver as observed previously [52, 53] or enhanced utilization of GSH for the detoxification of free radicals and oxidants produced as a result of EtOH exposure [17, 54-56]

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J Clin Oncol 30(27):3345-52, 2012
This is described by the Stern-Geary equation (equation 5.2)

AREs are sequences in the regulatory regions of genes that activate transcription of a diverse group of cytoprotective enzymes
