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In contrast, treatment of transfected HEK293 cells with isoproterenol resulted in 1 -AR phosphorylation by PKA and GRKs and decreased 1 -AR-dependent responses upon subsequent exposure to isoproterenol (Freedman et al., 1995)

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224 PPAR exert antioxidant and anti-inflammatory effects by down-regulating NF-B and other pro-inflammatory transcription factors

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