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It was previously reported that induction of apoptosis in the brain tissue resulted in neurotoxicity by MSG

These findings suggest that oral administration of glutathione may increase the incorporation of protein-bound glutathione into the liver or decrease the pathological excretion of glutathione from the liver

RNA sequencing and RNAPII-ChIP-Seq analyses demonstrate triptolide's biphasic impact on gene expression in pancreatic cancer (MIA PaCa-2) cells and cancer-associated fibroblasts, highlighting transcriptional down-regulation and specific alterations in histone acetylation [1020, 1021]

41 Slc3a2-dependent BCAA metabolism also has a key role in the physiological activities of Foxp3 + Treg cells, and either BCAA deprivation or SLC3A2 mutation can induce impaired activation of the mTORC1 pathway in Treg cells and inhibit the immunosuppressive function of Treg cells

Yet, these were deemed unlikely to be caused by the compound itself [21]