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Enzymatic properties and physiological roles As already mentioned, owing to the presence of a catalytic cysteine residue, Cys-GSTs have particular enzymatic properties since they should in principle catalyze deglutathionylation reactions by performing nucleophilic attacks on various GSH-conjugated substrates (Board et al., 2011)

Therefore, any imbalance in lipid metabolism may trigger a systemic inflammatory response that threatens neuronal survival and function

J Appl Toxicol JAT 32:505520 Laaksonen R, Katajamaa M, Piv H, Sysi-Aho M, Saarinen L, Junni P, Ltjohann D, Smet J, Van Coster R, Seppnen-Laakso T, Lehtimki T, Soini J, Orei M (2006) A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle

Therefore, exogenous expression in aged astrocytes of a cytoplasmically targeted PC gene could possibly decrease cellular senescence and inflammation from the senescence-associated secretory phenotype (SASP) to delay brain aging

Novel steroidal glycosides from the bulbs of Lilium pumilum