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Current prescribing information should be reviewed because pregnancy, lactation, and reproductive-risk information may change as new data become available.

If density declines significantly, interventions include calcium and vitamin D optimization, weight-bearing exercise, and sometimes pharmacologic therapy

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(Neelakantan et al., 2018) observed that systemic administration of NNMTi to mice with diet-induced obesity markedly attenuated WAT mass and body weight, diminished adipocyte volume, and reduced plasma TC levels

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