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L., RosFernndez R., OrtegoCenteno N., and RuedaMedina B

The mechanism of Se neuroprotection is attributed to modulation of Ca 2+ influx via ion channels, anti-inflammatory effect by abrogation of microglia invasion, and biosynthesis stimulation of antioxidative selenoproteins in the brain [100,101]

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Regulatory Status AOD-9604 is not FDA-approved for any medical use and is listed by the FDA as a bulk drug substance that may present safety risks. Clinical development was halted after Phase IIb trials failed to meet efficacy endpoints. Summary AOD-9604 is a synthetic analog of the HGH 177191 fragment developed for fat-metabolism research