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Acknowledgements The authors acknowledge NIH grants F30DK103511 (M.A.O.), T32HD007009 (M.A.O.), R01DK61931 (J.R.T.) and R01DK68271 (J.R.T.)

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This was a study we self-funded, and we paid for a top-class medical statistician to give an unbiased evaluation of the data collected for over four years

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This is likely due to an increase in miniature synaptic activity brought about by increasing dendritic spine densities and altering the morphological phenotype of postsynaptic spines

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