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The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease

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This reduction is directly linked to significantly lower levels of SCFAs, particularly butyrate 264

6.2 Iron metabolism pathway Iron overload has been shown to impair MM cell proliferation, an effect reversible by the ferroptosis inhibitor ferrostatin-1

Figure 2 2.2.1 CD8+ T cells CD8+ T cells, key immune effector cells in the TME, are involved in tumor clearance, as well as in responding to viral infections and other pathological conditions ( in vitro studies have demonstrated that glutamine deprivation can promote the differentiation of memory CD8+ T cells, facilitating the development of long-lasting immune memory ( in vivo inhibition of glutamine metabolism helps prevent CD8+ T cell exhaustion, sustaining their long-term effector functions ( 2.2.2 CD4+ T cells Upon antigenic stimulation, CD4+ T cells undergo metabolic reprogramming, activating pathways critical for their proliferation and differentiation ( via epigenetic mechanisms