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Ghodsi, R., Kheirouri, S., & Nosrati, R

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While praziquantel (PZQ) is the only available therapeutic, it faces significant limitations, highlighting an urgent need to discover novel drug targets and develop new anti-schistosomal agents

In each case, a slight change in the drugs target protein prevents binding without abolishing its normal function

The successful allele disruptions were validated by PCR using primers C1, C2, C3, and C4 (Supplementary Fig